What is Bacidal?

Sulfamethoxazole (Bacidal) and Trimethoprim (Bacidal) combination is used to treat infections such as urinary tract infections, middle ear infections (otitis media), bronchitis, traveler’s diarrhea, and shigellosis (bacillary dysentery). Sulfamethoxazole (Bacidal) and Trimethoprim (Bacidal) is also used to prevent or treat Pneumocystis jiroveci pneumonia or Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. This type of pneumonia occurs more commonly in patients whose immune systems are not working normally, such as cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS).

Sulfamethoxazole (Bacidal) and Trimethoprim (Bacidal) combination is an antibiotic. It works by eliminating the bacteria that cause many kinds of infections. Sulfamethoxazole (Bacidal) and Trimethoprim (Bacidal) will not work for colds, flu, or other virus infections.

Sulfamethoxazole (Bacidal) and Trimethoprim (Bacidal) is available only with your doctor’s prescription.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bacidal and other antibacterial drugs, Bacidal should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Urinary Tract Infections

For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis, and Proteus vulgaris. It is recommended that initial episodes of uncomplicated urinary tract infections be treated with a single effective antibacterial agent rather than the combination.

Acute Otitis Media

For the treatment of acute otitis media in pediatric patients due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when, in the judgment of the physician, Bacidal offers some advantage over the use of other antimicrobial agents. To date, there is limited data on the safety of repeated use of Bacidal in pediatric patients under two years of age. Bacidal is not indicated for prophylactic or prolonged administration in otitis media at any age.

Acute Exacerbations of Chronic Bronchitis in Adults

For the treatment of acute exacerbations of chronic bronchitis due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when, a physician deems that, Bacidal could offer some advantage over the use of a single antimicrobial agent.

Travelers’ Diarrhea in Adults

For the treatment of travelers’ diarrhea due to susceptible strains of enterotoxigenic E. coli.


For the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei when antibacterial therapy is indicated.

Pneumocystis jiroveci Pneumonia

For the treatment of documented Pneumocystis jiroveci pneumonia. For prophylaxis against Pneumocystis jiroveci pneumonia in individuals who are immunosuppressed and considered to be at an increased risk of developing Pneumocystis jiroveci pneumonia.


Bacidal combination is used to treat infections such as urinary tract
Bacidal combination is used to treat infections such as urinary tract

Use Bacidal suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Bacidal suspension by mouth with or without food.
  • Shake well before each use.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Bacidal suspension works best if it is taken at the same time(s) each day.
  • Take Bacidal suspension with a full glass of water (8 oz [240 mL]). Drinking extra fluids while you are taking Bacidal suspension is recommended. Check with your doctor for instructions.
  • To clear up your infection completely, take Bacidal suspension for the full course of treatment. Keep taking it even if you feel better in a few days.
  • If you are using Bacidal suspension to prevent an infection, continue to take it even if you feel well. Do not miss any doses.
  • If you miss a dose of Bacidal suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Bacidal suspension.

Use: Labeled Indications

Oral: Treatment of urinary tract infections (UTIs) due to

Escherichia coliKlebsiella and Enterobacter spp, Morganella morganiiProteus mirabilis, and Proteus vulgaris; acute otitis media; acute exacerbations of chronic obstructive pulmonary disease due to susceptible strains of Haemophilus influenzae or Streptococcus pneumoniae; treatment and prophylaxis of Pneumocystis pneumonia (PCP); traveler’s diarrhea due to enterotoxigenic E. coli; treatment of shigellosis caused by Shigella flexneri or Shigella sonnei.

IV: Treatment of PCP; treatment of shigellosis caused by S. flexneri or S. sonnei; treatment of severe or complicated UTIs due to E. coli, Klebsiella and Enterobacter spp, M. morganii, P. mirabilis, and P. vulgaris.

Off Label Uses

Bite wound infection, prophylaxis or treatment (animal or human bite)

Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of skin and soft tissue infections (SSTI), Bacidal, in combination with an appropriate agent for anaerobic coverage, is an effective and recommended alternative for the prophylaxis and treatment of animal bite wounds.

Clinical experience suggests the utility of Bacidal as an alternative agent for the prophylaxis and treatment of human bite wounds.

Toxoplasma gondii encephalitis (prophylaxis/treatment/chronic maintenance) in HIV-infected patients

Based on the US Department of Health and Human Services (HHS) guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents, Bacidal is an effective and recommended agent for primary prophylaxis of Toxoplasma gondii encephalitis and is an effective and recommended alternative agent for the treatment of or as chronic maintenance therapy of T. gondii encephalitis in HIV-infected patients.

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