Polygot is used for migraine pain. Orally, 1-2 tablets 2 times a day during a headache attack, then 1 tablet 2-3 times a day for several days (up to 1 month). Maximum single dose is 2 tablets, daily dose – 4 tablets. It is not recommended to use Polygot for a long time (to avoid ergotism): after 7 days of use in cases that require longer treatment, a break is made (for 3-4 days).
Headache in general and migraine in particular is one of the most common ailments. The WHO estimates that between 50 and 75% of the able-bodied population of the world have experienced headache during the last year. One third of them complained of migraine.
At the same time, the harm of migraine is globally underestimated, the attitude to this disease is sarcastically spitting. Meanwhile, according to 2013 data, migraine ranks sixth in the world in the number of years lived with disability.
Who is at risk? According to the WHO, the ailment affects people during puberty and peaks by the age of 35-45. It is noteworthy that women are much more susceptible to migraine. The number of applications to the doctor for this disease from women is recorded twice as often. It has also been established that migraine is genetic, so heredity plays an important role in the probability of occurrence of the disease.
As with other types of headache, the diagnosis of migraine is based mostly on the complaints of patients and does not require additional examination. The basis of diagnosis is a careful questioning of the patient and checking the complaints against the symptoms listed in the International Classification of Headaches.
Sometimes it is possible to identify objective symptoms, which may be reddening of the fingertips, as from a strong cold (Raynaud’s syndrome), moist palms, hyperexcitability of the facial muscles (Chvostek’s symptom), but in most cases the diagnosis of migraine can be made only on the basis of the patient’s complaints. Because of this, the WHO estimates that only 40% of patients receive a correct diagnosis.
The drug Polygot is a combination drug. Caffeine stimulates the central nervous system, mainly the cerebral cortex, respiratory and vasomotor centers. It increases mental and physical performance, reduces sleepiness and fatigue. It has a pronounced cardiotonic effect: it increases strength and heart rate, increases blood pressure in hypotension. Ergotamine has a vasoconstrictor effect. Caffeine accelerates absorption of ergotamine.
Polygot enhances pharmacological effect of drugs containing ergot alkaloids and caffeine. Caffeine is an adenosine antagonist (high doses of adenosine may be required). When caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin) are used together, metabolism and clearance of caffeine may be increased; cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin reduce caffeine metabolism in liver (slowing its excretion and increasing blood concentrations). Drugs that cause central nervous system stimulation – excessive stimulation of the central nervous system is possible. Mexiletine – reduces caffeine excretion by up to 50%; nicotine – increases caffeine excretion rate. MAO inhibitors, furazolidone, procarbazine, and selegiline – large doses of caffeine can cause dangerous cardiac arrhythmias or marked increases in blood pressure. Caffeine reduces the absorption of calcium preparations in the gastrointestinal tract. Reduces the effect of narcotic drugs and sleeping pills; increases the effect of non-narcotic analgesics (increased absorption).